What Makes G Protein-Coupled Receptors So Important in Medicine?

💡 The Answer

• GPCRs are the largest family of membrane proteins, with over 800 members in humans.
• They detect extracellular signals like light, hormones, and neurotransmitters.
• About 30-40% of all modern drugs target GPCRs.
• They activate intracellular G proteins to trigger cellular responses.
• Mutations in GPCRs cause many diseases, including blindness and cancer.